Michael Rein, M.D., and Mark Stoler, M.D., of UVA give the 2007 Gibson Lecture of the Cancer Center, discussing the new vaccine against cancer-causing strains of human papilloma virus that promises to virtually eradicate cervical cancer, yet Gardasil’s use is not without controversy. Who should be vaccinated? At what age? At what risks? Who decides? Should vaccination be mandatory? Who pays?